We Are Seneca’s Community Blood Center.

Seneca is surrounded by crystal-clear lakes, beautiful mountains, and passionate Clemson fans! We are grateful to also be surrounded by community members who are passionate about giving the gift of life to those who also call Seneca home. And, since we’re the ONLY blood provider for the Upstate, this gift is even more precious!

Therapeutic Services

The Blood Connection provides therapeutic phlebotomy as a community service at no charge, although a physician’s order is required.

1308 Sandifer Blvd. Seneca, SC 29678

For platelet/plasma and therapeutic donations, call 864.751.1168

Monday: 7:00 am - 7:00 pm
Tuesday: 7:00 am - 7:00 pm
Wednesday: 7:00 am - 7:00 pm
Thursday: 7:00 am - 7:00 pm
Friday: 7:00 am - 7:00 pm
Saturday: 7:00 am - 5:00 pm
Sunday: 7:00 am - 5:00 pm

South Carolina

Our staff will give you an amazing donation experience.

Our blood donation centers are staffed with friendly experts who want to make sure that your donation experience is as comfortable and rewarding as possible. It’s important to us that you feel at ease and rewarded for your selfless service. We are committed to treating you like the lifesaver you are!

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Friendly Staff

TBC staff go through rigorous training to serve as your guide through the donation process. Our team is dedicated to making sure you are taken care of every step of the way!

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Relaxed Environment

Take it easy for a bit as you give the gift of life. Our state-of-the-art centers are spacious and inviting, so you feel right at home.

Get Directions

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Complimentary Snacks & Drinks

Go ahead and grab a snack — you’ve earned it! There’s lots to choose from; chips and soda, cookies and coffee… the choice is yours. Only the best for lifesavers!


Lifesaving Donations

At our centers, you have the option to give whole blood, red cells, platelets, or plasma! To learn more about these donations and how they are used, ask our friendly staff when you donate.

How Do Your
Donations Help?

Always quick, efficient and professional. Very nice staff. It is a pleasure to go give at this facility.

— Real Seneca Center Blood Donor

GREAT Oconee staff

— Real Seneca Center Blood Donor

They were very nice and caring. The facility was very clean too. Not busy at all.

— Real Seneca Center Blood Donor

Always great service. Always clean and friendly!

— Real Seneca Center Blood Donor

The staff at Oconee TBC were amazing. I wasn't feeling well with just a few minutes remaining on my platelet donation. I let Kevin know and instantly was cared for by him and 3 other staff members. I am extremely grateful for the care shown to me. They made a difference in my experience and I will be returning as long as I can to donate knowing I will get great care.

— Real Seneca Center Blood Donor

The staff at the Seneca Blood Connection is all amazing!

— Real Seneca Center Blood Donor

Become a Lifesaver
by Donating Blood Today!