A generation of Greenville citizens has grown up knowing blood will be available in an emergency thanks to The Blood Connection and the support of many local donors. But it wasn’t always that way.


A group of physicians, hospital and civic leaders decided on a plan to serve the needs of patients in the community and formed The Greenville Blood Assurance Plan.


The Greenville Blood Assurance Plan was officially merged into a new organization called Carolina-Georgia Blood Center.

This created a central resource for collecting and processing blood and blood products, ensuring patients access to blood available in the region.


The board of trustees adopted the mission-oriented name, The Blood Connection. This name more accurately reflected the organization’s mission – to ensure an adequate, safe, and cost-effective blood supply for its healthcare partners.

The Blood Connection expands into 4 more locations throughout the Upstate of SC and into NC. Also, a new modern brand identity was created to establish a set of standards that will help maintain a sense of continuity as more regions are added.


TBC also started servicing the Raleigh, NC area in 2017. A donor center and distribution hub opened on July 23, 2018 on Glenwood Avenue. As service to the Eastern and Coastal North Carolina region continues to expand, TBC opened a second processing facility in Morrisville.

In 2019, TBC began serving hospitals in the Charleston, SC area. The grand opening for the North Charleston donation center, distribution hub, and reference lab was February 27th, 2020.

And now TBC’s reach in South Carolina and Georgia is even greater as 2021 hosted three donation center grand openings. TBC officially opened its Florence, SC donation center in March, followed by the Lexington, SC donation center in June, and lastly, the Savannah, GA donation center opened in November. TBC opened its newest center in Anderson, SC in June of 2023.